The purpose of the study is to assess if curcumin, a natural plant extract and spice, can regress colorectal and duodenal adenomatous polyps in patients with familial adenomatous polyposis (FAP).
Ages Eligible for Study: 18 Years to 85 Years
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
Familial Adenomatous Polyposis
Patients with intact colons
Patients with surgery: ileostomy, Ileo-rectal Anastomosis (IRA) or J-pouch
18 years to 85years old
5 or more adenomas of the colorectum
Female patients of childbearing age not on effective birth control.
Patients with WBC less than 3500/ml
Platelet count less than 100,000/ml
BUN greater than 25
Creatinine greater than 1.5
Patients unable to stop NSAIDS, aspirin,tumeric,curcumin, calcium, VitD, green tea, polyphenol E supplements for the duration of the trial
Malignancy other than nonmelanoma skin cancer.
Active bacterial infection.
Patients with symptoms of active GERD (symptomatic despite medication or current erosive esophagitis on endoscopy).
Patients with a history of peptic ulcer disease
Patients on Warfarin or Plavix.